NIH awards UH Cancer Center researchers over $2.8M to study lung cancer disparities

March 17, 2020

University of Hawaiʻi Cancer Center researchers, S. Lani Park, MPH, PhD, and Lenora Loo, PhD, were awarded a five-year $2.8 million grant from the National Institute on Minority Health and Health Disparities (NIMHD) of the National Institutes of Health , to study smoking-related lung cancer disparities across different racial and ethnic populations.

S. Lani Park
Lenora Loo

“This is the first study of its kind to molecularly characterize smoking-related lung cancer across different racial and ethnic groups. Lung tumor biology may be a key contributor to the disparities in lung cancer risk and survival,” said Park, study co-principal investigator and UH Cancer Center associate researcher.

Park and Loo will use data and biospecimens from the Multiethnic Cohort (MEC) Study to characterize the molecular profiles such as DNA methylation and gene expression of lung adenocarcinoma, the most common subtype of lung cancer, from different racial and ethnic groups. The racial and ethnic populations being studied include African Americans, Japanese Americans, Latinos, Native Hawaiians and Whites.

Previous findings showed that even after accounting for known lung cancer risk factors, such as smoking history, Native Hawaiians and African Americans are at greater risk of disease compared to Whites. Japanese Americans and Latinos were found to have a lower risk of lung cancer compared to any of the above three studied populations. Moreover, survival across the five populations are not equal.

“We hope that the findings from this study will provide new information on the biological mechanisms that contribute to the racial and ethnic disparities of lung cancer, so that new personalized treatment targets and strategies can be developed to mitigate these disparities,” said Loo, study co-principal investigator and UH Cancer Center associate researcher.

UH Cancer Center Hawaiʻi Tumor Registry

  1. Leading cause of cancer deaths in men and women in Hawaiʻi is lung cancer
  2. Lung cancer is the 2nd most common cancer for men and women in Hawaiʻi
  3. There are about 776 cases of lung cancer in Hawaiʻi each year